diff --git a/serde/src/de/impls.rs b/serde/src/de/impls.rs
index 6c4ad5ea..5e0eba3b 100644
--- a/serde/src/de/impls.rs
+++ b/serde/src/de/impls.rs
@@ -2242,10 +2242,17 @@ nonzero_integers! {
     NonZeroU16,
     NonZeroU32,
     NonZeroU64,
-    // FIXME: https://github.com/serde-rs/serde/issues/1136 NonZeroU128,
     NonZeroUsize,
 }
 
+// Currently 128-bit integers do not work on Emscripten targets so we need an
+// additional `#[cfg]`
+serde_if_integer128! {
+    nonzero_integers! {
+        NonZeroU128,
+    }
+}
+
 ////////////////////////////////////////////////////////////////////////////////
 
 impl<'de, T, E> Deserialize<'de> for Result<T, E>
diff --git a/serde/src/ser/impls.rs b/serde/src/ser/impls.rs
index 5a1952e4..cafd53cd 100644
--- a/serde/src/ser/impls.rs
+++ b/serde/src/ser/impls.rs
@@ -469,10 +469,17 @@ nonzero_integers! {
     NonZeroU16,
     NonZeroU32,
     NonZeroU64,
-    // FIXME: https://github.com/serde-rs/serde/issues/1136 NonZeroU128,
     NonZeroUsize,
 }
 
+// Currently 128-bit integers do not work on Emscripten targets so we need an
+// additional `#[cfg]`
+serde_if_integer128! {
+    nonzero_integers! {
+        NonZeroU128,
+    }
+}
+
 impl<T> Serialize for Cell<T>
 where
     T: Serialize + Copy,